The RG421EXL features a mahogany body with binding bolted to a maple Wizard III neck with a 24-fret rosewood fingerboard with binding and white dot position markers. Components include dual Ibanez Quantum humbucking pickups and a fixed bridge.

• neck type: Wizard III/Maple neck
• top/back/body: Meranti body
• fretboard: Bound Jatoba fretboard/White dot inlay
• fret: Jumbo frets
• number of frets: 24
• bridge: F106 bridge
• string space: 10.5mm
• neck pickup: Quantum (H) neck pickup Passive/Ceramic
• bridge pickup: Quantum (H) bridge pickup Passive/Ceramic
• factory tuning: 1E,2B,3G,4D,5A,6E
• strings: D'Addario® EXL110
• string gauge: .010/.013/.017/.026/.036/.046
• hardware color: Black