The S520 features a mahogany body bolted to a maple Wizard III neck with a 24-fret rosewood fingerboard with offset dot position markers. Components include dual Ibanez Quantum humbucking pickups and an Edge Zero II double locking tremolo bridge with a locking nut. For 2018 the rosewood fretboard was replaced by jatoba. For 2019 the mahogany body was replaced by meranti. For 2021 the fretboard reverted to rosewood.